čas: 19.4.2021 04:57:35
Obnovit | RAW
Department of Solid State Engineering
List of available PhD theses
A new generation of materials and approaches for detecting and destroying of pharmaceutical contaminants in the aquatic environment
Advanced bactericidal coatings with long-lasting effect
Experimental work focused on the optimization of immobilization of metal nanoparticles on polymeric supports for the preparation of a new generation of antimicrobial surfaces. Nanoparticle immobilization will be acomplished by physical methods based on the interaction of prepared particles with laser radiation. Antibacterial effects and biocompatibility of developed surfaces will be evaluated in cooperation with the Department of Biochemistry and Microbiology VŠCHT Prague.
Advanced materials for green hydrogen preparation
Advanced methods and applications of SERS
Advanced structures and materials for surface enhanced Raman spectroscopy
Hydrogels based on poly(vinyl alcohol)
This work deals with the preparation and characterization of hydrogels films based on PVA. Hydrogels will be modificated physically (plasma, laser radiation) or/and chemically (doping with nanoparticles, drugs, dyes, etc.). Changes in surface and mechanical properties depending on the modification will be studied. The antibacterial properties and cytocompatibility of the prepared hydrogels will be determined.
Intelligent materials and surfaces - switching between "ultra" states
New concept of enhancing targeting of polymer conjugates for drug delivery to brain
The aim of the Ph.D. thesis is to develop a conceptually new system for inhibition of glutamate carboxypeptidase II (GCP II) in brain as a treatment tool for suppressing glutamate toxicity and subsequent neuroinflammation-caused secondary damage after ischemic, hemorrhagic or traumatic brain injuries (which typically damage brain and spinal cord more than the primary injury and are the reason why neural damage often gets worse within few days after first occurrence of symptoms). The delivery system will modify the unfavorably hydrophilic properties of the GCP II inhibitors, which are normally unable to cross the blood-brain barrier (BBB). The delivery system will also enhance inhibitor potency by forming multivalent physically self-assembled („molecular toolbox“) biocompatible polymer-coated solid lipid nanoparticles. The inhibitor-containing nanoparticles will decompose after crossing the BBB by apolipoprotein E-mediated transfer and the polymer-bound inhibitor will become reversibly membrane-anchored in the proximity of the membrane-bound GCP II. This membrane anchoring is expected to be a generally applicable concept for targeting also enzymes or receptors other than GCP II.
Photochemistry on the base of noble metals nanostructures
Plasmon- and electro-chemical active materials for relevant chemical transformations
Polymer-bound reactive oxygen species precursors for cancer therapy
Radiation therapy applies ionization radiation to cancer tissue to elicit the reactive oxygen species (ROS) production to kill the cancer cells. The radiation treatment can be boosted by application of radiosensitizers. The aim of this thesis is to prepare a polymer material that is able to deliver artificial ROS into the cancer cells or deliver precursors that will trigger the ROS generation at the place of action. Moreover, specific hypoxic markers can be utilized for active targeting to hypoxic tumor tissue. The student will design and prepare polymer systems which will be releasing ROS as: superoxide, peroxides or singlet oxygen in desired cancer site. The project is highly multidisciplinary, it includes polymer and organic syntheses, characterization techniques such as FTIR, 1-H 13-C NMR, SEC, DLS, SAXS and SANS. Moreover, the student can participate on biological studies which will be performed on collaborating workplace. If the student is interested in, it is possible to make part of the study at collaborating workplace in France within the program “double degree PhD”, the deadline is February 14, 2020 (see https://studium.ifp.cz/cz/doktorandi/barrande-fellowship-program/ ). If you are interested in this option, please contact the supervisor as soon as possible.
Polymeric nanomaterials for neoadjuvant multimodal therapy of advanced neoplastic diseases
The main aim of this work will be the development of new multi-component biocompatible and non-immunogenic polymer-based nanotherapeutics and nanodiagnostics adapted for multimodal advanced therapy of neoplastic diseases. The dissertation will be based on the preparation of new polymeric nanomaterials that will allow the controlled delivery of active therapeutic agents or tumor visualization for fluorescently navigated surgery. These nanomaterials will serve as a tool for multimodal neoadjuvant therapy based on sequential administration of chemotherapy and immunotherapy in combination with fluorescently navigated surgery. The work will focus on tailor-made solutions using covalent binding of active molecules with several functions: targeted transport of active molecules, their protection during transport against degradation and controlled release based on site-specific stimuli. The thesis will consist in the design, synthesis and study of physico-chemical and biological properties of polymeric materials. The applicant's knowledge and experience in organic or macromolecular chemistry is an advantage, along with the desire to learn new things in other fields, such as biochemistry. The work assumes close cooperation with cooperating biological teams in the Czech Republic and abroad.
Regeneration of CO2 using renewable energy sources
SERS and artificial neural network – toward the analysis of complex biochemical samples
Smart antimicrobial materials
Smart materials for medical and biological applications
Smart materials for optics and electronics
Study and application of nanostructures induced by high energy excimer laser
The work will focus on the study of the interaction of polymeric materials with a unique high-power excimer laser. Periodic nanostructures on a polymer will be studied, especially their applications in the field of tissue engineering with a focus on the possibility of single cell analysis. Periodic nano-patterns (LIPSS) will be used to monitor the interaction primarily with mammalian cells, as well as their antibacterial properties, especially in combination with selected surface active substances. The work will also focus on the exposure of thin carbon nanolayers and carbon composites. Within the interaction of materials with a high energy excimer laser, also the possibilities of preparation of new materials, such as Q-carbon with ferroelectric properties, will be investigated.