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Chemical and Process Engineering

Doctoral Programme, Faculty of Chemical Engineering

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Careers

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Programme Details

Study Language	Czech
Standard study length	4 years
Form of study	combined , full-time
Guarantor	prof. Ing. František Štěpánek, Ph.D.
Place of study	Praha
Capacity	25 students
Programme code (national)	P0711D130015
Programme Code (internal)	D401
Number of Ph.D. topics	45

Complete Curriculum

Application period is not open now

Ph.D. topics for study year 2024/25

CO2 capture. Industrial process optimization.

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

Annotation

CO₂ capture belongs to frequent industrial needs, both in the cases of low concentration CO₂ removal from waste gases and in the cases of main process streams, e.g., in hydrogen production, when high amount/concentration is to be removed. Just the last example represents the process, which the PhD thesis will be focused to. In the premises of Unipetrol company, the CO₂ capture unit is presumed to be permanently optimized. In accordance with the needs of the industrial partner, the experimental research goals will involve i) durability / degradability of the solution currently used in the process, ii)absorption efficiencies and selectivities (H₂S/CO₂) of new absorbents and iii)the influence of low concentration admixtures, e.g., Fe, Ni and V metals, on the CO₂ capture efficiency. The PhD student will acquire valuable experience of industrial area life because he/she will be able independently act in the Unipetrol premises, will cooperate with industrial research department UniCRE and will find here both well-equipped laboratories and experienced consultants.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Particle agglomeration and fouling in liquid- and gas-dispersion polymerization reactors

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Juraj Kosek

Annotation

Agglomeration and fouling of particles are the undesired phenomena in many polymerization reactors, e.g., in emulsion, suspension, slurry and gas-dispersion processes. These undesired phenomena negatively affect the quality of products and can even cause shut-down of polymerization processes due to fouling of heat transfer surfaces and loss of fluidization. This PhD thesis will focus primarily on catalytic polymerization of olefins in liquid-dispersion (slurry) and gas-dispersion (fluidized or stirred-bed) reactors. Qualitative theoretical explanation of phenomena causing or affecting the agglomeration/fouling is available, but this explanation is scattered in various branches of science. Therefore the first goal of PhD thesis will be the systematic organization of physico-chemical picture involving particle-particle, particle-wall and particle-fluid interactions. The considered description will involve van der Waals interactions, chain entanglement dynamics, effect of swelling on elastic modulus and particle collision dynamics, electrostatic charging of particles, osmotic stabilization of dispersions, lubrication forces, turbulent mixing conditions, effect of particle size distribution and particle surface texture, heat transfer effect, liquid bridges and thermodynamics of species sorption. For the quantitative understanding of agglomeration and fouling processes, we need the conduct series of well-designed systematic experiments aiming at: (i) measuring the dynamics of agglomeration / fouling in reactors, (ii) characterization of particle and dispersion mixture properties, and (iii) characterization of particle-particle, particle-wall and particle-fluid interactions. In this respect, the laboratory is equipped with all the required equipment involving mixed reactor, AFM, micro-CT, DSC, TD-NMR, rheometry, sorption/diffusion/swelling measurements, digital image processing etc. This PhD project is primary experimental, but the student will conduct also limited DEM (discrete element method) modeling enabling the testing of various hypotheses. The outcomes of PhD thesis will have a broad impact both to fundamental science (experimental studies and systematic data are scarce) and to practical applications (mitigation strategies suppressing unwanted phenomena in agglomeration and fouling). Prospective PhD student is expected to spend a term in some European laboratory with similar research interests and to take some responsibility for the contractual industrial research. Info: phone 220 44 3296, office B-145, e-mailjkk@vscht.cz, webhttp://kosekgroup.cz

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Diagnostics of two-phase flows in microchannels

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	Ing. Jaroslav Tihon, CSc.

Annotation

The aim of this project is to experimentally investigate the character of two-phase (gas/liquid) flow in microchannels. The mapping of different flow regimes will be performed for different microchannel configurations (e.g. channel crossing, T-junction, sudden expansion) and different model fluids (Newtonian, viscoelastic, pseudoplastic). The electrodiffusion method, an original experimental technique developed in our department, is used to determine the liquid flow in the near-wall region and to detect the characteristics of translating bubbles. The visualization experiments with a high-speed camera and the velocity field measurements with the mPIV technique will provide additional information about the flow structure in microchannels. The candidate should have a Master's degree in chemical engineering or a similar applied science field. He/she should have experimental skills for laboratory work and some basic knowledge of hydrodynamics. However, enthusiasm for independent scientific work is the most important requirement. The candidate will certainly benefit from our long experience in experimental (computer-controlled measurements with subsequent data processing in LabView) and theoretical (solving complex hydrodynamic problems in MatLab or Mathematica) fluid mechanics.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Dynamical behavior of polydisperse granular materials during the mixing process

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	doc. Ing. Jaromír Havlica, Ph.D.

Annotation

This PhD project focuses on the investigation of the complex dynamics inherent in polydisperse granular systems during mixing processes. The focus is on uncovering the mechanisms governing both the unifying homogenization tendencies and the segregation inclinations of particles within these systems and predicting their collective impact on system behavior. The research will consist mainly of discrete element method numerical simulations, which are instrumental in clarifying the dynamics of granular materials under varying mixing conditions. Experimental measurements will be used to validate the simulations, thereby bridging theoretical models with real-world behavior. The results of this research are expected to have significant applications in the chemical and pharmaceutical industries. Required education and skills • Master's degree in chemical engineering, mathematical modeling, and computer science; • high motivation, willingness to learn new things; • team spirit.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Bubble dynamics in aqueous solutions of organic compounds with hydrogen bonds

Granting Departments:	Department of Chemical Engineering
Supervisor:	doc. Dr. Ing. Pavlína Basařová

Annotation

Aqueous solutions of simple alcohols (C1-C3) exhibit anomalous behaviour due to the internal arrangement at the molecular level, which significantly affects a number of physical quantities and processes. Bubble behaviour is also of great interest, where the alcohol concentration in solution affects the mobility of the phase interface. This further determines the bubble velocity and mass transport. Other surfactants or salts are present in real systems. The aim of this work is to study these systems in the model case of an isolated bubble and a cluster of bubbles in an aerated column. The work should result in a generalization of the mechanism of how the microstructure of solutions affects bubble dynamics. The PhD student is expected to participate in grant projects and actively participate in international scientific conferences. The work includes measurement of bubble dynamics using a high-speed camera, image processing, construction of small-scale equipment for conducting experiments and interpretation of the obtained results. Required education and skills: university degree in chemical engineering or physical chemistry; systematic and creative approach to work and ability to work in a team.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Dynamics of multi-phase systems: gas-liquid-solid

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	doc. Ing. Marek Růžička, CSc. DSc.

Annotation

Multiphase systems are all around us, in nature and in industry technologies and applications (sedimentation, fluidization, bubble columns, flotation apparatuses, etc.). Due to the complexity and applicability of these systems, it is seriously worth to study their hydrodynamic aspects. The present PhD research will focus on the experimental and theoretical description of processes controlling multiphase dispersions at microscale level (like bubble coalescence, bubble-particle collision) and their consequences on the flow regimes at the macroscale level (bubble columns, flotation apparatus, etc.). The obtained results will be valuable in many industrial applications (chemical and oil industry, food processing, metallurgy, pharmaceutical and environmental industry). Requirements • Master degree in chemical or mechanical engineering, or physics and mathematics • ability and willingness to study • creative approach and team-work

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Physiologically based pharmacokinetic modelling of drug release from long-acting injectable formulations

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Injectable depot formulations represent a rapidly emerging class of drug delivery systems that offer convenience for the patients, good adherence to medication, avoidance of side effects such as gastric irritation, and theoretically 100% bioavailability. Depot systems often have the form of a suspension of drug of prodrug particles in an aqueous vehicle that also includes stabilisers, viscosity modifiers, tonicity agents and other components. The drug release from intramuscular depots is a non-trivial process that includes particle surface dissolution, diffusion within the depot and the surrounding tissue, enzymatic conversion of the prodrug to the parental drug, absorption into systemic circulation, and eventually biodistribution and elimination from the body. There is an acute need for robust and physiologically relevant mathematical models of drug release from depot systems to enable rational formulation decisions such the effect of particle size distribution or the overall applied dose on the time-dependence of drug plasma concentration in the patient. The aim of this project is to develop, validate and apply such models in collaboration with an industrial partner.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

<i>In-situ</i> formation of volatile antibiotics from microstructured materials and their use in topical treatment

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Ondřej Kašpar, Ph.D.

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Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Inhalational drug nanocrystals for systemic delivery

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Denisa Lizoňová, Ph.D.

Annotation

This PhD project will focus on the design, preparation, and optimization of an aerosol drug nanocrystal fabrication process as a promising strategy for systemic delivery of poorly soluble low molecular weight drugs via the inhalation route. With a primary focus on nanocrystal preparation and aerosolization, the research aims to develop efficient techniques for the production of inhalable drug nanocrystals. The study will investigate different methods of nanocrystal preparation (wet milling, continuous precipitation) and evaluate their effectiveness in producing stable monodisperse nanocrystals that allow for better drug dissolution and thus higher bioavailability. In addition, the research will focus on the development and validation of aerosolization devices to ensure optimal drug delivery of nanocrystals. Through this research, the thesis aims to contribute to the development of non-invasive drug delivery methods, which will ultimately facilitate the introduction of new therapeutic agents into clinical practice. The student will learn techniques for the preparation and characterization of nanocrystals, the preparation and characterization of aerosols, and other methods necessary for the research project. In addition, the student will have the opportunity to collaborate within a multidisciplinary research team and present and publish their research.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Ionic transport in membrane systems

Granting Departments:	Department of Chemical Engineering
Supervisor:	doc. Ing. Zdeněk Slouka, Ph.D.

Annotation

Daná práce se zaměří na výzkum v oblasti separace iontových složek z vodných roztoků pomocí selektivních membrán.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Morphology dependent phenomena in energy storage

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Alexandr Zubov, Ph.D.

Annotation

Dnešní doba klade stále větší nároky na technologie pro vysokokapacitní mobilní úložiště elektrické energie, jež jsou nezbytná pro lepší využití obnovitelných zdrojů energie, budování chytrých elektrických sítí a rozšíření elektromobility. V úložištích energie se na různích úrovních projevuje důležitost heterofázové morfologie. Příkladem může být vnitřní porézní struktura membrán a elektrod, či dendrity vznikající u jejich povrchu. Tato práce se zabývá ději ovlivněnými morfologií v rámci úložišť energie. Příkladem takového jevů může být právě růst dendritů – útvarů o rozličné morfologii vznikajících elektrodepozicí kovu na povrchu elektrod. Dendritické útvary snižují životnost i kapacitu baterie a mohou vyústit v přehřívání a zkrat článku. Práce je teoretického charakteru, bude tedy realizována primárně skrze nástroje matematického modelování.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Liposomal reservoirs for non-equilibrium encapsulation of bioactive compounds

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Liposomes are spherical vesicles composed of a phospholipid bilayer surrounding an aqueous cavity. Liposomes can be used as drug carrier systems, but their capacity is limited by the thermodynamic solubility of the encapsulated substance in the aqueous phase and its partitioning into the lipidic membrane. For this reason, the practical applications of liposomes are not as numerous as they could be. The aim of this project is to develop and demonstrate a method of substantially increasing the drug carrying capacity of liposomes and make it independent of thermodynamic solubility of the compound. Strategies for achieving these goals will include simultaneous liposome formation and substance crystallisation from a supersaturated solution either by cooling or by solvent evaporation or building the liposomes around a concentrated nanosuspension of the drug, or hydration of a solid dispersion of the drug in a lipidic matrix. Once such high-load liposomes are formed, they will be tested for bioavailability enhancement of poorly soluble or enzymatically degradable drugs, for side effect elimination of drugs that irritate the GI tract, or for drug application by injection. Furthermore, such liposomes will be used as miniature reservoirs that make it possible to control chemical reaction kinetics in an ON/OFF manner thanks to the reversible phase transition of the membrane.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Remotely controlled gated magnetic nanoadsorbents

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Adsorbents are porous materials with a high internal surface that are capable of reversible and selective accumulation of solutes in their pores. Adsorbents are typically used for industrial separation or purification processes, but they can also be applied as sensors to accumulate an analyte, or as drug delivery systems to release a previously loaded bioactive substance. One limitation of adsorbents is that being based on weak non-covalent interactions, the solutes can spontaneously desorb when the adsorbent passes through an environment with lower bulk concertation of the solute, or when competing solutes are present. The aim of this project is to develop adsorbents coated by a phospholipid membrane that will act as a gating mechanism to allow temperature controlled ON/OFF diffusion depending on the phase transition of the lipid bilayer. To enable manipulation with such adsorbents, they will also contain magnetic nanoparticles, which can simultaneously act as susceptors for radiofrequency heating. Thus, solute accumulation or release from the adsorbents can be temporally and spatially controlled from a remote source. Such nano-devices will be used for collecting solutes from complex microenvironments such as biological tissues of biofilms, and for drug delivery and controlled release to such environments.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Mathematical modeling of continuous-flow bioreactors and bioseparators

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. Michal Přibyl, Ph.D.

Annotation

Microfluidic devices are characterized by a large surface-to-volume ratio. This can be used in the efficient separation of special chemicals using extraction, membrane and other processes. The separation of optically active substances, important pharmaceutical products or circular economy intermediates is a challenge for contemporary chemical engineering. Mathematical modeling can lead to a better understanding of the complex reaction-transport phenomena in such devices and to the design of efficiently operating microfluidic reactors and separators. The main goals of the proposed PhD project are: description of the kinetics of reactions catalyzed by free and/or immobilized enzymes in microreactors, development of a mathematical-physical description of mass and momentum transport in microseparators with an imposed electric and/or magnetic field, optimization of modular microreactors-separators in order to achieve a high degree of conversion and high separation efficiencies. The models will be studied using approximate analytical techniques and numerically using the COMSOL program. Our laboratory is equipped with powerfull workstations and PCs. It is assumed that the doctoral student will be involved in grant projects and active participate at international scientific conferences.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Membrane separation of fermentation primary products

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

Annotation

In biotechnologies, batch processes are often used, in which living cultures/biomass are used. Metabolites produced by culture are often poisonous and can damage the culture itself, as an example of which can serve ethanol fermentation. In periodic processes, the initial periods including sterilizing, nutrient dosing, etc., used to be time consuming, financially burdening. Therefore, it is desirable to dedicate an effort to develope continuous performance of such processes. One of the operations ensuring the process continualization can be membrane separation. This case brings the necessity of two membranes modules: i) microfiltration to separate solid particles-biomass and ii) pervaporation to separate primary product of fermentation, e.g., ethanol, as mentioned above. The goal of this work is to experimentally develop two step membarne separation technique, including microfiltration and pervaporation, to be prepared for an interconnection with a fermenter. THe development will be conducted from the viewpoint of chemical engineering. The reached separation parameters (selectivity, permeability) will be investigated in dependency on the process parameters (pressure, flowrate, temperature, feed composition). Chemical engineering quantities (membrain polarization module, mass transfer coefficient,...) will be used to describe these dependencies. At the workplace the new membrane modules are available, which were purchased for the purpose of this development. The PhD student will get familier both with industrial membrane module and with the custom made one. In addition to being familiar with modern technologies introduced in industry, the PhD student will also work in the team of students and academic staff who are experienced in industrial cooperation. PhD study will prepare the student to obtain either qualified working position in industry or to be able systematically conduct further research from the viewpoint of qualified chemical engineer. Further information Assoc. Prof. Tomáš Moucha, UCT Prague, building B, room T02, email: tomas.mooucha@vscht.cz

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Microcapsule Vivaria: A Novel Approach for Investigating Microbial Communication Pathways

Granting Departments:	Department of Chemical Engineering
Supervisor:	doc. Ing. Jitka Čejková, Ph.D.

Annotation

Microbial communication pathways play a crucial role in various ecological and biotechnological processes. However, studying these pathways can be challenging, particularly when signals are unknown or consist of unstable mixtures. Traditional methods necessitate prior knowledge of the signaling substance, which may not always be available. To address this limitation, this dissertation proposes a novel approach: encapsulating small populations of microorganisms within semi-permeable microcapsules. These capsules serve as miniature vivaria, enabling live microbial cultures to communicate via chemical signals while preventing physical escape or overgrowth by competing microbes. The capsules, designed with core-shell structures and embedded magnetic particles, offer remote manipulation and recovery capabilities. By controlling the permeability of the shell, the dissertation systematically investigates the role of individual chemical species in microbial communication. This innovative approach offers unprecedented capabilities, including the ability to emit or absorb multiple chemical signals, analyze signal concentration gradients, pre-condition microorganisms, and maintain host status while sensing microbial presence. Moreover, it facilitates the study of multispecies interactions within complex environments. Overall, the dissertation demonstrates that microcapsule vivaria represent a promising tool for uncovering the mysteries of microbial communication pathways, with implications for ecology, biotechnology, and beyond.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Microstructured catalytic layers for electrochemical fuel cells

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. Petr Kočí, Ph.D.

Annotation

The work is devoted to microstructured catalytic layers used in catalytic converters of gaseous mixtures and electrochemical fuel cells of the SOFC type (solid oxide fuel cell). It includes development of suitable catalytic materials for the use of ammonia as an alternative fuel to hydrogen, either directly in the fuel cell, or after reforming in a catalytic converter. The topic is addressed in cooperation with National Taipei University of Technology, Taiwan.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Bioreactors Design Parameters - Experimental study of transport characteristics in various apparatuses

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

Annotation

The efficiency of new biotechnology and pharmaceutical products manufacture also depends on a suitable bioreactor selection. In the design of an optimal bioreactor, they key parameters are the maximum yield of a primary product and, simultaneously, the lifetime of the used microorganisms. The aim of the doctoral study is to compare the design parameters (transport characteristics such as volumetric mass transfer coefficient, gas hold-up and energy dissipation intensity) of three types of the most commonly used bioreactors. The results will be used to characterize the differences and similarities of specific types of bioreactors in terms of gas distribution, mass transfer and mixing depending on the total energy supplied to the system. Transport characteristics will be obtained experimentally for model batches, which will be designed based on physical properties of real broths. The work is intended as the cooperation of UCT Prague (supervisor's workplace) with ICPF Prague (consultant's workplace) and appropriatley complements the second PhD topic offered by the consultant. Both cooperating workplaces are equipped by necessary facilities i) mechanically stirred reactor, ii) bubble column and iii) air-lift reactor. All bioreactors are adapted to measure transport characteristics by the same methods, therefore the results will be comparable. Requirements for an applicant: master degree in chemical or mechanical engineering, organic technology, biotechnology etc.; ability for teamwork; systematic and creative approach to scientific problems; interest in experimental work

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Eavesdropping in microscale - microencapsulation of microbiota and study of their cross-talk

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Viola Tokárová, Ph.D.

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Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Advanced flow batteries for stationary energy storage

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Juraj Kosek

Annotation

Energy decarbonisation is one of the biggest technological and social challenges of the coming decades. The ability to efficiently and safely store large amounts of electricity produced by intermittent renewable sources is an essential prerequisite for securing the increasing energy needs of our societies. Flow batteries represent a promising alternative to today's more widespread solid-state batteries based on Li-ion. However, their broader commercionalization is still obstructed by several techno-economical challanges such as low energy density, high cost of electrolytes and battery stacks. Within this dissertation student will research and develop strategies towards increase of energy and power density of flow batteries using both organic and inorganic redox active species. This will be apporached by various ways including use of electrolyte additives, suspension flow batteries and solid-state capacity boosters with redox mediation. Also the possibility of flow battery hybridization with metal deposition or gas phase electrodes will be thouroughly studied, both experimentaly and theoretically using state-of-art characterization devices and methods. The output of the doctoral thesis will be not only a series of publications, but also practical knowledge leading to the improvement of flow battery-based technologies with regard to energy density, efficiency and durability. The doctoral student will collaborate on the project not only in a team of doctoral students and post-docs at our workplace, but also with partners from several companies and universities. Info: tel. 220 44 3296, doors: B-145, e-mail jkk@vscht.cz, web http://kosekgroup.cz/en

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Advanced manufacturing concepts for flexible dose combinations

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Fixed dose combinations (FDC) are drug products containing two or more active pharmaceutical ingredients whose combined therapeutic effect has been proven to be superior to that of individual components. Numerous clinical studies show significantly improved life expectancy of patients using FDC compared to their individual counterparts, especially in the cardiovascular area. For large therapeutic areas, it is common to develop FDCs e.g. in the form of bi-layer tablets for the most prescribed combinations of drugs and their strengths, e.g. candesartan and amlodipine. However, smaller, or more marginal patient cohorts are not served by this approach. The aim of this project is to develop and implement novel manufacturing concepts based on the post-mixing of mass-produced single-component subunits (e.g. minitablets), and thus achieve flexibility for small batch manufacturing of FDC products with a broader range of dosage strength combinations and/or interchangeable active ingredients.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Polymerization - Production renewal

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

Annotation

Polyvinyl chloride, PVC, means the product of a wide usage in industry and households. This product is marketed for decades. It resulted in several ways of manufacturing it, the effectiveness of which is permanently increased. This work aims on the renewal of polymerizaion technology in Spolana Neratovice Co. Because the work will be carried out in the cooperation with this industrial company, the student will get familier with the industrial environment and with the way of the work there.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Population balance method for bubble column reactors, with organic liquids

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	MSc. Sandra Kordac Orvalho, Ph.D.

Annotation

Bubble columns are commonly used in industry for bioprocesses, toluene hydrogenation for hydrogen transport or oligomerization of ethylene. However, predicting the bubble size distribution in a bubble column under specific operating conditions remains a major challenge for the scientific community, especially in the case of presence of an organic liquid phase. The present project proposes to build up a breakthrough methodology based on both small and large scales experiments to determine breakage and coalescence kernels in organic liquids. The main goal of the PhD proposal consists in making a link between small scale experiments under controlled conditions (determination of bubble breakup frequency and coalescence efficiency) to the bubble size distributions in bubble columns. Further aim is to use the experimentally collected data to test and improve population balance method for bubble column reactors with organic liquids. Required education and skills • Master degree in chemical or mechanical engineering or in physical chemistry; • Systematic and creative approach to scientific research, teamwork ability.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Process measurement of hydrogen concentration - Development of a measurement device prototype Hmeter

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

Annotation

Hydrogen usage broadens across many industrial branches. Therefore, its concentration measurement becomes more important. We further focus on one of the H₂ concentration measurement techniques, which ingeniously employs chemical engineering aspect of diffusion, especially to the measurement in a primary coolant of nuclear power plants (NPP). While a plenty of companies offer oxygen sensors suitable for the measurement in the primary coolant, the hydrogen sensor, really selective to H₂ concentration, is offered rarely. For this reason, the functional sample of hydrogen sensor was developed in the Mass Transfer Laboratory, including its verification in the NPP Dukovany. This work aims to develope the prototype rising from the verified functional sample. The development covers a wast variety of activities as, e.g., the SW development to control measurement regimes of the sampling channels, H-sensor, temperature and pressure signals recording and evaluation, as well as the design of sampling ways and attending their realisation. The experience gained during the development of oxygen concentration measurement in recent years will be used. The project is also financially supported by the Technological Agency of the Czech Republic and the student will be incorporated to the project. Not only will the student get familiar with an academic research methods but also will get to know the specifics of the operational measurement, including modern data acquisition systems.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Gas - Liquid Mass Transfer. Experimental comparison of various apparatuses performance - Cotutelle with UNIPA

Granting Departments:	University of Palermo Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

Annotation

The volumetric mass transfer coefficient (kLa) plays a crucial role in industrial design in the case of the process controlled by gas–liquid mass transfer. Prediction of kLa is nowadays mostly based on literature correlations. Our research goal is to establish suitable kLa correlations for different types of devices that would be based on the experimental dataset. The PhD thesis aim at the comparison of various gas-liquid contactor types from the viewpoint of their mass transfer efficiency. The suitable correlations will be developed that would be viable for mechanically agitated gas–liquid contactors and also for pneumatically agitated gas–liquid contactors such as airlift reactor.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Separation of enantiomers by membrane processes

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Physical Chemistry
Supervisor:	Doc. Ing. Pavel Izák, Ph.D., DSc.

Annotation

The aim of the PhD thesis is the separation of racemic mixtures by membrane separation processes. The racemic mixtures contain the same amount of L and D enantiomers. The individual enantiomers have the same physicochemical properties in the achiral environment and therefore it is very difficult to separate them. However, in the human body L and D enantiomers have different effects and the D enantiomers may be harmful to health. PhD work will focus on the development of new membranes and separation techniques for the selective separation of enantiomers from racemic mixtures with practical applications, particularly in the pharmaceutical, food or agrochemical industries. The PhD candidate will be required to work out a detailed search of foreign literature on the subject (need for active English knowledge), independent measurement and results processing, and in cooperation with the supervisor and to write publications in foreign periodicals. Required education and skills • Master degree in chemical engineering, physical chemistry, organic technology, chemical physics; • willingness to do experimental work and learn new things; • team work ability.

Contact supervisor Study place: Department of Physical Chemistry, FCE, VŠCHT Praha

Shear stress in mixed dispersions - experimental and numerical study to design fermenters better

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

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In fermentation technologies, mechanically agitated aerated vessels are frequently used. In cases of aerobic fermentations, the Oxygen Uptake Rate - OUR is frequently used as the important design parameter. This means that the gas-liquid mass transfer controlled process is considered and the volumetric mass transfer coefficient - kLa is taken as the most important parameter. The practice shows, however, that the impellers with lower Power number (which means lower turbulence intensity and lower kLa) often ensure higher bioprocess efficiency than those with high Power number (which means higher turbulence intensity and higher kLa). The explanation is brought by the fact that microorganisms/biomass might be damaged by the high turbulence intensity as explained further. The turbulence intensity is proportional to shear stresses occuring in the mechanically agitated fermentation batch. A high shear stress may "cut" the microorganisms, which stop producing their primary product then. The aim of PhD thesis is to measure the quantities proportional to shear stress values at the process conditions of aerobic fermentations, as local gas hold-ups or bubble size distribution are, and couple them with the kLa values, which are already at disposal in the Mass Transfer Lab database. Thanks to the cooperation with the teams of technical mathematicians from UCT Prague and Czech Technical University, resulting experimental data series will be completed by the shear rate values computed. In the frame of the cooperation with the mathematicians, a scientific project involving a foreign company producing and selling agitators and vessels is now being prepared. The PhD student will attend the project. Resulting experimental and computed data connection will enable to develop the highly efficient, rational industrial fermenters design tool.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Study of bubble cluster dynamics in aerated columns

Granting Departments:	Department of Chemical Engineering
Supervisor:	doc. Dr. Ing. Pavlína Basařová

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Rychlost a velikost bublin má v aerovaných kolonách nebo bioreaktorech klíčový vliv na transport kyslíku a celkový obsah plynu. Ve větších kolonách však není možné detailněji sledovat tvary a rychlosti bublin. Obecně je známo, že chování izolované bubliny, chování shluku bublin a bublin v koloně se liší. Cílem práce je stanovit vliv fyzikálních vlastností roztoku (viskozita, hustota, povrchové napětí, vliv rozpuštěných látek) na chování izolovaných bublin v reálné aerované koloně a porovnat je s chováním shluku bublin. Výsledkem práce bude parametrická studie zkoumající tvar, velikost a rychlost bublin v závislosti na průtoku plynu, mechanismu vzniku bublin a fyzikálních vlastností roztoku. Předpokládá se podíl doktoranda/ky na řešení grantových projektů a aktivní účast na mezinárodních vědeckých konferencích. Požadované vzdělání a schopnosti: VŠ absolvent oboru chemické inženýrství nebo fyzikální chemie; systematický a tvůrčí přístup k práci a schopnost týmové spolupráce.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Study of hydraulic and transport characteristics of random and structured packings under absorption conditions

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Lukáš Valenz, Ph.D.

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Při současném prosazování rate-based přístupu k modelování dějů v plněných kolonách dochází k potížím se souhlasem dat získaných na různých pracovištích s různými systémy. Tato práce má popsat rozdíly v datech získaných na jednom pracovišti, na stejném experimentálním zařízení ale se dvěma běžně používanými systémy a kvantifikovat rozdíly.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Investigation of cell interaction with nano/microstructured surfaces

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Viola Tokárová, Ph.D.

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Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Investigation of collective phenomena in lipid membrane permeation

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Permeation of small molecules across lipid bilayer lies at the essence of physiological processes such as cell homeostasis or application processes such as drug delivery. For a long-time, pemeation has been considered a unary property of the permeant, but recent experimental evidence suggests that non-trivial interactions can occur during the co-permeation of multiple solutes simultaneously. Both acceleration and retardation of permetaion has been observed, and the equilibrium water-lipid partitioning coefficient has been affected as well. The aim of this project is to understand the underlying mechanisms that govern solute interaction during co-permeation across lipidic bilayers using computational methods. Using a combination of Molecular Dynamics and appropriate mean-field based approaches, hypothesis regardding co-permeation and co-partitioning will be tested. Specifically, the “crowding out” and “crowding in” hypotheses of co-permeation will be explored computatinoally. The knowledge gained in the simulations will be used for the rational design of co-permeants, for the explanation of potential drug interactinos, and for establishing engineering principles of liposomal formulations.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Triboelectric routes enabling plastic waste separation and recycling

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Juraj Kosek

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Recycling is the most beneficial and eco-friendly way to treat large amount of plastic waste. However, conversely to a public belief, the majority of plastic waste is burned in incineration plants or stored in landfills instead of being recycled. The bottleneck of the plastic waste treatment originates in the pre-separation, as only precisely separated waste can be recycled. Even the incineration process requires the pre-separation of plastics, mainly the removal of polymers containing halogens that could otherwise form harmful gases during combustion. Current methods like manual separation, IR spectroscopy or methods based on density differences aren’t sufficiently effective. The new promising technique, triboelectric separation, is based on the idea that each plastic material reaches different electrostatic charge by tribocharging (charging by friction) and therefore charged plastic mixtures can be separated in electric field. The objective of this Ph.D. project is the establishment of experimental bases (systematic series of data) related to charging and discharging dynamics in powders, which will provide integrated description of these phenomena. The student will also investigate opportunities for control of surface charge and subsequent separation of dielectrics in electric field. The student shall challenge several open problems: (i) relation between ESC and mechanical/chemical properties of materials, (ii) electric charge dissipation, (iii) charging of powders under the conditions simulating real industrial production of industrially important powders, (iv) the effect of charge on fouling, (v) charging for separation and recycling of plastic materials. The project is a pioneering work which is desperately needed and is sufficiently challenging for a student with interest in physico-chemical fundamentals of previously described processes. The student will work with highly qualified Ph. D. students and postdocs in our research group and will also cooperate with our European partners. Our laboratory is well prepared for the research of electrostatic processes (Faraday cup, corona charging, high-voltage separator) and characterization of powder texture and material properties (micro-tomography, atomic force microscopy – AFM). Info: phone 220 44 3296, office B-145, e-mailjkk@vscht.cz, web http://kosekgroup.cz

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Influence of liquid content on granular material mechanics

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	doc. Ing. Jaromír Havlica, Ph.D.

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This PhD project aims to dissect the intricate mechanics of granular materials under the influence of varying liquid content, a critical factor in numerous industrial and natural processes. Central to this investigation will be the use of Discrete Element Method simulations, which provide a granular-level perspective on how liquid saturation affects particle interactions, force distributions, and emergent mechanical properties. By adjusting the liquid content parameters within these simulations, the research will seek to model and understand phenomena such as capillary action, liquid bridge formation, and the transition from dry to wet granular states. Complementing the computational approach, targeted experiments will be performed. The synergy between simulation and experimentation is expected to provide a comprehensive understanding of fluid-induced dynamics in granular systems, paving the way for improved material handling, processing techniques, and predictive capabilities in complex environments. Required education and skills • Master's degree in chemical engineering, mathematical modeling, and computer science; • high motivation, willingness to learn new things; • team spirit.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Effect of interfacial properties on dynamics of bubbles

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	MSc. Sandra Kordac Orvalho, Ph.D.

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Multiphase systems consisting of a gas phase dispersed in a liquid environment are omnipresent in nature and in living systems. Gas-liquid contact is also responsible for the success of many industrial processes, such as flotation, or aerated reactors. Surfactants, SAS, with their ability to lower the interfacial tension between gas-liquid phases, alter the behavior of many multiphase processes, and for many systems, the characterization of the interface by surface tension alone is not enough and less conventional measurements of surface rheology and SAS adsorption/desorption characteristics are crucial. The aim of this work is to determine experimentally the influence of surfactants on the dynamics of processes with bubbles (movement, dissolution, coalescence, etc.) and to characterize selected SASs by measuring relevant physico-chemical and transport properties. The typical work will include measurements of interfacial rheology, observations of bubble dynamics by high-speed camera, but also building single-purpose experimental equipment and physical interpretation of results. Required education and skills • Master degree in chemical or mechanical engineering or in physical chemistry; • Systematic and creative approach to scientific research, teamwork ability.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Caprolactam Production - Industrial Optimization

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Dr. Ing. Tomáš Moucha

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This work will significantly expand the cooperation started two years ago on the demand of Spolana Co. So far, batchelor thesis is the only output of the incipient cooperation in this field. Caprolactam, the intermediate in Nylon production, is offered for decades and several manufacturing ways are described. It´s production is permanently optimized. This work aims to a systematic description of all the processes in the technology and mapping the process parameters, which could be used in the optimization. The optimization criteria will be, e.g., the product purity, rafinate purity or other parameters which affect the technology environmental impact. Thanks to the cooperation with industrial partner the student will not only cooperate with the team of other students and teachers at UCT but will also get the experience with the industrial environment and the way of working there.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Application microfluidic devices to study interdisciplinary problems in fields of chemical engineering and medical diagnostics

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	doc. Dr. Ing. Petr Klusoň

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Microfluidic devices play a key role in bridging the fields of chemical engineering and medicine, enabling interdisciplinary exploration. These miniaturized systems manipulate small fluid volumes, offering precise control for studying biological processes and drug delivery. In chemical engineering, microfluidics aid in optimizing reactions, enhancing process efficiency, and developing advanced materials. Simultaneously, in medicine, these devices facilitate intricate analyses of cells, biomolecules, and disease mechanisms. This thesis will address the integration of microfluidic devices to study the progression of chemical and biological processes in field of personalized medicine and diagnostics. The candidate should have an interest in chemistry or biochemistry and has good relation to experimental laboratory work to perform tests with microfluidic devices, as well as with data acquisition and evaluation. To complete the delegated tasks, the personal abilities such as independence, creativity, open mind and team work skills will be required.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Application of microreactors for study of gas phase catalytic reactions

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	Ing. Petr Stavárek, Ph.D.

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Microreactors are promising devices that are increasingly finding widespread application in many chemical processes. The advantage of microreactors is that, with a suitable geometrical design with respect to the process to be studied, their reaction space geometry allows to study reactions or test catalysts under conditions without limitation by mass and heat transport. Therefore, the scope of the present topic is to study catalytic gas-phase reactions using a microreactor in order to optimize the design. The work will include experimental laboratory tests with model reactions, data processing, mathematical description of kinetics and transport variables with the aim of designing the microreactor for the optimal course of the studied reaction and maximum spatial yield. The ideal candidate should have a strong knowledge of chemical and reaction engineering, as well as a positive attitude towards using data acquisition systems, data evaluation, and mathematical modeling. Independence, creativity, teamwork skills, a willingness to learn, and proficiency in the English language are also required for this role.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Development and testing of inhalable dry powder formulations for drug delivery

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Ondřej Kašpar, Ph.D.

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Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Development and utilization of advanced in vitro models for inhalational drug delivery

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Denisa Lizoňová, Ph.D.

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The main objective of this Ph.D. project is to develop highly organized cell culture models of the human respiratory tract, which can be used for studying systemic drug delivery through inhalational route. Specific Objectives: 1. Development of an in vitro alveolar air-liquid interface model using alveolar cell lines to study drug absorption and particle translocation through the alveolar barrier. 2. Establishment of an in vitro tracheobronchial (TB) model using TB epithelial and goblet cell lines to investigate drug nanocrystal permeation and retention in the mucus barriers. 3. Characterization of drug absorption, translocation, and mucus penetration properties of aerosolized drug nanocrystals using the developed in vitro lung models. 4. Optimization of nanocrystal size and surface chemistry (in collaboration with other research team members) to enhance drug absorption, minimize macrophage uptake, and improve mucus penetration for efficient systemic delivery. Apart from the research itself, the student will have the opportunity to collaborate within a multidisciplinary research team and present and publish their research

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Construction of physics-informed artificial intelligence for industrial process control

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Jan Haidl, Ph.D.

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With the development of artificial intelligence, new opportunities for genuinely autonomous control of industrial processes emerge. One of the key features that artificial intelligence systems pose is seeking patterns in extensive data collection. Contrary to the classical operation paradigm of control systems monitoring pre-defined process variables, AI systems monitor the whole process, enabling the prediction of future system development and identifying potential risks before they arise. On the other hand, contemporary AI systems are also known for their low generalization and extrapolation capabilities, resulting in the need for enormous training datasets and unexpected behavior outside the scope of training data, for example, if one or multiple data inputs fail. To address these weaknesses, the concept of a hybrid -- physics-informed -- artificial intelligence was tested by various researchers, showing significant improvement in both mentioned issues. The hybrid system comprises an artificial neural network and a physical or semi-empirical model of the process, combining the AI computational performance and capability to seek patterns with the process's fundamental models limiting the AI outputs. Several case studies proved that physics-informed neural networks require significantly less training data and offer better extrapolation capabilities than conventional systems. The dissertation topic aims to develop a framework for a hybrid autonomous system capable of controlling the whole industrial process of drinking water treatment. The work consists of experimental work as well as mathematical modeling. In cooperation with programmers, water treatment specialists, and industrial partners, you will develop a hybrid AI system combining artificial neural networks with the engineering models of individual processes in a drinking water treatment facility - coagulation, filtration, adsorption, disinfection, etc. The models will be calibrated and validated using the data from a pilot-plant water treatment facility; the same facility will be used for hybrid system evaluation. The facility enables us to calibrate and test the system operation under acceptable conditions (producing drinking water) as well as under extreme situations resulting in production failure, promising system robustness and reliability. If the pilot tests succeed, the system will be further tested with industrial partners on full-scale water treatment plants.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Co-processed active pharmaceutical ingredients for direct compression

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Active pharmaceutical ingredients (APIs) in high-dose tablets (e.g. metformin, ibuprofen) would benefit from as little dilution by excipients as possible to keep the tablet weight down, while maintaining processability (bulk density, flow behaviour, compressibility, etc.). Co-processing is a rapidly emerging approach that aims to combine the API with a small amount of excipient while achieving large differences in processability, usually by the modification of surface properties, particle size and morphology. The aim of this project is to explore co-processing concepts for several chosen APIs based on both dry and wet routes, and to demonstrate that co-processed APIs can be manufactured in a scalable and reproducible manner. The ultimate aim is to utilise co-processes APIs in direct compression, i.e. the manufacturing of high-dose tablets without any granulation step.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Development of a microfluidic platform for pathogen separation and sorting from biological fluids

Granting Departments:	Department of Chemical Engineering
Supervisor:	Ing. Viola Tokárová, Ph.D.

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Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Development of advanced methodology for in vitro testing of long-acting injectable depot systems

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Injectable depot systems (also called Long Acting Injectables -- LAIs) represent an increasingly popular class of drug delivery systems that offer convenience for the patients, good adherence to medication, avoidance of side effects such as gastric irritation, and theoretically 100% bioavailability. However, there are no established methods for in vitro characterisation of drug release from LAI, or for their bioequivalence testing or in vivo-in vitro correlations. Also, there is a need for accelerated in vitro models, especially for LAIs that last for several months under in vivo conditions. Drug release from LAI depots comprises several elementary steps such as particle dissolution, drug diffusion and enzymatic conversion in the surrounding tissues, drug absorption into systemic circulation, and drug elimination. The aim of this project is to develop and test a series of in vitro methods for the characterisation of LAI, which can be based e.g. on hydrogel matrices, hollow-fibre membrane modules, or 3D cell cultures (artificial muscles). The objective will be to test the reproducibility and bio relevance of such models, as well as their incorporation into a typical workflow of a pharmaceutical R&D laboratory.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Enhancing design and efficiency of rotating thermal processors: a modeling and experimental approach

Granting Departments:	Institute of Chemical Process Fundamentals of the CAS, v.v.i. Department of Chemical Engineering
Supervisor:	doc. Ing. Jaromír Havlica, Ph.D.

Annotation

Rotating thermal processing equipment plays a pivotal role in industry, providing the controlled and uniform heating essential for processing bulk materials. Optimizing such equipment depends on understanding the dynamics of the system, as this has a direct impact on energy consumption, processing time, and the mechanical integrity of the materials involved. This PhD project will investigate the optimization of granular material behavior in rotating thermal processing equipment using the Discrete Element Method (DEM) for simulations complemented by experimental validations. DEM simulations will be performed to model discrete particle interactions in order to optimize the dynamical behavior of these materials. Experimental work will validate and refine these models to ensure their accuracy and applicability in industrial settings. The synergy of simulation and experimental results aims to improve equipment design and process efficiency, with broader implications for the materials processing industry. Required education and skills • Master's degree in chemical engineering, mathematical modeling, and computer science; • high motivation, willingness to learn new things; • team spirit.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Scale-up of wet nanomilling and nanocrystal formulation processes

Granting Departments:	Department of Chemical Engineering
Supervisor:	prof. Ing. František Štěpánek, Ph.D.

Annotation

Dried nanocrystalline suspensions of poorly soluble active pharmaceutical ingredients (APIs) have been shown to be superior to amorphous solid dispersions in terms of dissolution rate enhancement, stability, excipient dilution, and manufacturing simplicity. The formation of aqueous nanosuspension can be achieved in wet stirred media mills that can be operated in a batch mode during process development and then scaled up to flow-through arrangement either in recirculation or single-pass mode. The suspension can then be easily dried to obtain granular material suitable for direct capsule filling or direct tabletting. The aim of this project is to develop and validate a robust scale-up methodology for the manufacturing of nanocrystal suspensions by flow-though wet milling at the highest possible concentration, subsequent spray during or fluid-bed drying, and processing into a final dosage form (tablets, capsules). For a chosen API, the entire process from raw API to finished products will be demonstrates and the product pharmaceutical performance (stability, in vitro dissolution, in vivo bioavailability) will be evaluated.

Contact supervisor Study place: Department of Chemical Engineering, FCE, VŠCHT Praha

Updated: 25.3.2022 18:16, Author: Jan Kříž