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Studentská vědecká konference 2019

Harmonogram SVK 2019

  • Vyhlášení SVK 2019
  • Uzávěrka podávání přihlášek: 21. 10. 2019
  • Uzávěrka nahrávání anotací: 8. 11. 2019
  • Datum konání SVK: 21. 11. 2019 - VÝSLEDKY

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Děkujeme všem sponzorům SVK 2019 na FCHI!

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prof. RNDr. Petr Slavíček, Ph.D.

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Chemical Engineering II (B141b - 8:30)

  • Předseda: doc. Ing. Zdeněk Slouka, Ph.D.
  • Komise: Sandra Kordač Orvalho, Ph.D., Ing. Denisa Lizoňová, Ing. Kateřina Hejnová (BRE), Ing. Pavel Calta, Ph.D. (Kapaji)
Čas Jméno Ročník Školitel Název příspěvku Anotace
8:40 Bc. Filip Hládek M1 prof. Ing. František Štěpánek, Ph.D. Protocells: Comparison of approaches for controlled release detail

Protocells: Comparison of approaches for controlled release

One of the problems of newly synthetized drugs is their poor water solubility. That can be solved either by amorphization or by loading into a carrier. Though liposomes have been used as carriers, they are not able to effectively carry all APIs. Protocell, that is a mesoporous silica nanoparticle (MSN) core encapsulated within a liposome, might be the solution to that. MSNs are capable of absorbing APIs and improving their solubility and the liposome bilayer prevents leakage and premature release of the loaded API.     Thus, the combination of MSNs and liposomes was studied experimentally, exploring the possible means of preparation of protocells. The data were evaluated in means of size distribution, surface charge and morphology, confirming the results by TEM imagery. This work compares the different approaches in order to develop the most appropriate preparation method. 
9:00 Bc. Jan Šugar M1 Ing. Viola Tokárová, Ph.D. Temperature-responsive polymer-coated particles for steady cell growth and temperature controlled harvesting detail

Temperature-responsive polymer-coated particles for steady cell growth and temperature controlled harvesting

There is a growing demand for a variety of cells in biotechnology and advanced medicine which pushes the cultivation techniques development further. Moreover, successful cultivation is not only about cell growth, whereas the harvesting seems to play a crucial role in compromising some of the cell features, e.g. cell viability, extracellular proteome, contamination with additives etc. Therefore, utilizing a temperature-controlled harvesting might be a promising method since the temperature drop is easily carried out and causes insignificant stress. The authors will focus on development of novel nanostructured particles coated with temperature-responsive polymer undergoing the hydrophilic/hydrophobic change in a suitable temperature range. These particles will be fabricated to support the anchorage-dependent cell lines to enable their successful growth in perfusion mode either in fluidized bed or agitated bioreactor. The newly developed technique will be validated mainly by the fluorescence microscopy allowing reliable recognition of viable and apoptotic cells or by enzyme activity assays confirming the intactness of cell surface proteins.
9:20 Oskar Marelja B3 Ing. Martina Ježková Comparison of experiments and numerical models of microfluidic channels   detail

Comparison of experiments and numerical models of microfluidic channels  

Comparison of experiments and numerical models of microfluidic channels    The science of microfluidics is on the rise, and so-called lab-on-a-chip laboratories have high potential for chemical and bio-medical applications. These chips minimize material consumption while maximizing surface and hence phase-to-phase contact. In nano- and micro-scales, the effect of interfacial processes is significant and it is therefore essential to have information about the shape of the interfacial surface as well as the events that are realized through this surface - such as mass transfer, heat transfer and molecule rearrangement to minimize the interfacial energy.  The purpose of this study is to compare the experimental observations of fluid interactions in different microchannels with numerical models created with ANSYS Fluent. Once validated, these models will be in the next step used to predict the behavior of fluids within a microchannel and optimize the geometry of the microchannel without the necessity to perform complicated experiments. Two modelling approaches were taken and compared: the Volume of Fluid and the Mixture method. The finding of 4 different interaction phenomena - dripping, squeezing, jetting and tubing - taking place at the microchannel junction was further approved.       
9:40 Bc. Adam Baláž M1 Mgr. Fatima Hassouna, Ph.D. Formulation of porous poly(lactic-co-glycolic acid) microparticles for controlled drug release detail

Formulation of porous poly(lactic-co-glycolic acid) microparticles for controlled drug release

Poly (lactic-co-glycolic acid) (PLGA) in the form of micro- and nano-particles has attracted much attention for applications in drug delivery systems thanks to its tunable degradation rate. In this work, porous microparticles loaded with various model molecules, i.e. Ibuprofen, Curcumin and Indomethacin were prepared. Physico-chemical properties of the formulations were analyzed by IR, XRD and DSC and the drug loading was determined by UV-visible. The role of the porogen in the preparation of the porous particles and its impact on their final properties were investigated. The impact of the nature of the drug on the morphology and on the drug release performance in a simulated lung environment (pH = 7.4) was assessed and conclusions were drawn. These microparticles can find applications in lung cancer treatment.  
10:20 Bc. Martin Šourek M2 Ing. Martin Isoz, Ph.D. Pore-scale model development for catalytic material washcoating in a filter wall detail

Pore-scale model development for catalytic material washcoating in a filter wall

The increasingly stringent automotive emission regulations enforce the use of particulate filters to effectively control the particulate emissions from both diesel and gasoline engines. Due to the cost and size limitations of the exhaust gas after-treatment system, it is favorable to combine the particulate filter with a catalytic reactor for conversion of gaseous pollutants. The properties of the resulting catalytic filter are highly dependent on the quality of the catalytic coating. This study focuses on a development of methodology for simulation of the washcoating process, as one part of a reliable multi-scale CFD modeling environment for catalytic filters. To describe the flow, particle-particle and particle-wall interactions in the water-based slurry during the washcoating we propose a coupled CFD-DEM solver. Initial solver implementation, definition of suitable benchmark cases and intended solver usage are presented.
10:40 Bc. Pavel Krýsa M1 doc. Ing. Miroslav Šoóš, Ph.D. Characterization of composite drug particles prepared by dry coating detail

Characterization of composite drug particles prepared by dry coating

Dry coating process is an alternative method to a conventional film coating. This process results in formation of a coating on the surface of drug particles during application of mechanical forces. The protective layer is made out of an appropriate excipient, mostly a deformable polymer. So prepared powder material can be subsequently utilized in different areas. Among them are stabilization of metastable forms of APIs, controlling the drug release characteristics or influencing powders flow properties. Because this process often takes place in milling devices, the success of dry coating is difficult to predict. Therefore, in this work we are focusing on general understanding of the process. Investigated parameters include ratio of particle size and mass of drug and excipient, size and amount of milling balls, and milling frequency. In our case, we are working with a model system that consists of a drug paracetamol and a coating polymer carnauba wax. To minimize impact of particle size during dissolution tests, obtained coated drug particles are sieved into several size fractions. These defined classes are subsequently characterized with a combination of several analytical techniques including SEM, dissolution experiments or Raman mapping.   
11:00 Bc. Tomáš Lapka M1 Mgr. Fatima Hassouna, Ph.D. Optimization of conductive films for electromagnetic shielding applications detail

Optimization of conductive films for electromagnetic shielding applications

Electromagnetic waves as an important carrier of information have infiltrated all aspects of life thanks to the rapid development of information technology and electronic devices. Electromagnetic interferences (EMI) caused by electromagnetic waves do not only interfere with electrical equipment, but they are also a serious threat to human health. Therefore, in recent years, designing of lightweight and effective materials for EMI shielding applications has gained attention. Polypyrrole (PPy) is an electrically conductive polymer, which can be prepared with different shapes. Each shape has unique properties and behavior. PPy nanotubes (PPy-NT) have attracted much attention due to their high electrical conductivity (up to 100 S·cm-1). Incorporation of PPy-NT into cellulose nanofibrils (CNF) results in formation of flexible and electrically conductive thin films. This study deals with the elaboration of PPy/CNF thin films with optimal morphology, mechanical properties and electrical conductivity for applications in EMI shielding. The processing conditions were optimized to tune the properties of the films. Finally, EMI shielding tests in the range of 5,85 – 8,20 GHz were carried out on the most electrically conductive films.  

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Aktualizováno: 28.11.2019 18:49, Autor: Jitka Čejková

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